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Proceedings Paper

On selectivity and gating of ionic channels
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Paper Abstract

A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.

Paper Details

Date Published: 8 June 2007
PDF: 11 pages
Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020D (8 June 2007); doi: 10.1117/12.724703
Show Author Affiliations
D. G. Luchinsky, Lancaster Univ. (United Kingdom)
Ames Research Ctr. (United States)
R. Tindjong, Lancaster Univ. (United Kingdom)
P. V. E. McClintock, Lancaster Univ. (United Kingdom)
I. Kaufman, The Russian Research Institute for Metrological Service (Russia)
R. S. Eisenberg, Rush Medical College (United States)


Published in SPIE Proceedings Vol. 6602:
Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov, Editor(s)

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