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Proceedings Paper

A new model for myosin dimeric motors incorporating Brownian ratchet and powerstroke mechanisms
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Paper Abstract

A new dimer model is introduced to describe the behavior of dimeric processive motor proteins in general. A single motor domain is modeled using our previous work on hybrid motors that exhibit elements of both a powerstroke and a Brownian motor mechanism. The different behavior observed in Myosins V and VI can be explained by varying the physical parameters describing the coupling between the two motor domains. The dynamics of the resulting stepping mechanics under loaded and unloaded conditions are examined. The results from this dimer model are compared with experimental data for two-headed processive motors.

Paper Details

Date Published: 8 June 2007
PDF: 11 pages
Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 660206 (8 June 2007); doi: 10.1117/12.724693
Show Author Affiliations
Brian Geislinger, Univ. of Alabama at Birmingham (United States)
Ryoichi Kawai, Univ. of Alabama at Birmingham (United States)


Published in SPIE Proceedings Vol. 6602:
Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov, Editor(s)

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