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Proceedings Paper

Evaluation of drug release from PLGA nanospheres containing bethametasone
Author(s): Mohammad E. Khosroshahi; Marjan Enayati; Sara Shafiei; Javad Tavakoli
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Paper Abstract

In this research poly (d,l-lactide-coglycolide acid) (PLGA) as polymeric nanospheres, poly(vinyl alcohol) (PVA) with 87-89% hydrolysis degree as surfactant and distilled water as suspending medium were used. The encapsulated drug was Bethametasone. The nanospheres were prepared by an emulsion-solvent evaporation method. The nanospheres characterized by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). The amount of drug release was determined by HPLC. In emulsion-solvent evaporation technique, time of ultrasound exposure, surfactant content in the formulation and evaporation rate of organic solvents were considered as formulation variables.

Paper Details

Date Published: 13 July 2007
PDF: 11 pages
Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66331E (13 July 2007); doi: 10.1117/12.724480
Show Author Affiliations
Mohammad E. Khosroshahi, Amirkabir Univ. of Technology (Iran)
Marjan Enayati, Amirkabir Univ. of Technology (Iran)
Sara Shafiei, Amirkabir Univ. of Technology (Iran)
Javad Tavakoli, Amirkabir Univ. of Technology (Iran)

Published in SPIE Proceedings Vol. 6633:
Biophotonics 2007: Optics in Life Science
Jürgen Popp; Gert von Bally, Editor(s)

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