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Proceedings Paper

A new class of nontoxic nanoparticle tags based on surface enhanced Raman scattering
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Paper Abstract

The advance of nanotechnology has boosted the development of ultra-sensitive biosensors for biomedical applications. Most recently, optical detection based biosensors have been demonstrated in medical imaging and diagnosis employing nanocrystals such as fluorescent quantum dots (QDs) and plasmon resonant metal nanoparticles to achieve femto-molar detection. An intriguing but far less explored approach for biological diagnostics relies on an emerging ultrasensitive technology -- surface enhanced Raman scattering (SERS) spectroscopy. We have developed a stable SERS nano-tag by grafting hydrophilic polymer to gold nanoparticle-dye molecule complexes to preserve the spectral signature and fully control the aggregation states. The light-emitting power and scattered light of both QDs and SERS nano-tags have been recorded under the same experimental conditions using dark field microscope, fluorometer, and Raman instrument. A comparison in brightness, sensitivity level, and quantum efficiency between SERS nano-tags and near infrared (NIR) QDs has been assessed on both bulk colloidal solution and single particle measurements. Well-designed SERS nano-tags exhibit excellent advantages over NIR QDs.

Paper Details

Date Published: 27 February 2007
PDF: 12 pages
Proc. SPIE 6448, Colloidal Quantum Dots for Biomedical Applications II, 64480O (27 February 2007); doi: 10.1117/12.718459
Show Author Affiliations
X.-M. Qian, Emory Univ. (United States)
D. Ansari, Emory Univ. (United States)
Shuming Nie, Emory Univ. (United States)

Published in SPIE Proceedings Vol. 6448:
Colloidal Quantum Dots for Biomedical Applications II
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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