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Proceedings Paper

Mapping tissue chromophore changes in cerebral ischemia: a pilot study
Author(s): David Abookasis; Marlon S. Mathews; Christopher Lay; David J. Cuccia; Ron D. Frostig; Mark E. Linskey; Bruce J. Tromberg
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Paper Abstract

We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.

Paper Details

Date Published: 23 March 2007
PDF: 7 pages
Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64242J (23 March 2007); doi: 10.1117/12.718430
Show Author Affiliations
David Abookasis, Beckman Laser Institute and Medical Clinic, Univ. of California/Irvine (United States)
Marlon S. Mathews, Beckman Laser Institute and Medical Clinic, Univ. of California/Irvine (United States)
Univ. of California/Irvine (United States)
Christopher Lay, Univ. of California/Irvine (United States)
David J. Cuccia, Beckman Laser Institute and Medical Clinic, Univ. of California/Irvine (United States)
Ron D. Frostig, Univ. of California/Irvine (United States)
Mark E. Linskey, Univ. of California/Irvine Medical Ctr. (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic, Univ. of California/Irvine (United States)
Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 6424:
Photonic Therapeutics and Diagnostics III
Henry Hirschberg; Brian Jet-Fei Wong; Reza S. Malek; Kenton W. Gregory; Nikiforos Kollias; Bernard Choi; Steen J. Madsen; Guillermo J. Tearney; Justus F. R. Ilgner; Haishan Zeng, Editor(s)

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