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Experimental investigation of magnetic nanotubes in PC-12 neuron cells culturing
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Paper Abstract

This report discusses the effects of magnetic nanotubes on the differentiation and growth of neurons. The magnetic nanotubes used in this study are hematite nanotubes synthesized using template method, and their structural and magnetic properties have been characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). PC-12 cells are differentiated into neurons in the presence of magnetic nanotubes to confirm the biocompatibility and cytotoxic effects of magnetic nanotubes during the processes of neuron differentiation and neuronal growth. The morphological changes and synapse formation of neurons are investigated, and the contact effects of magnetic nanotubes on neurite (axon and dendrites) outgrowth are explored. This research allows us to understand the interaction between magnetic nanomaterials and neurons, and pave the way towards developing potential treatments using the magnetic nano tubes for neurodegenerative disorders and injuries to the nervous system in the future.

Paper Details

Date Published: 11 April 2007
PDF: 9 pages
Proc. SPIE 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007, 65280L (11 April 2007); doi: 10.1117/12.717970
Show Author Affiliations
Linfeng Chen, Univ. of Arkansas (United States)
Jining Xie, Univ. of Arkansas (United States)
J. Yancey, Arkansas State Univ. (United States)
Malathi Srivatsan, Arkansas State Univ. (United States)
Vijay K. Varadan, Univ. of Arkansas (United States)

Published in SPIE Proceedings Vol. 6528:
Nanosensors, Microsensors, and Biosensors and Systems 2007
Vijay K. Varadan, Editor(s)

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