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Proceedings Paper

Biochemical detection with optical whispering-gallery resonaters
Author(s): Ying Lin; Vladimir Ilchenko; Jay Nadeau; Lute Maleki
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Paper Abstract

We demonstrate biochemical detection based upon specific binding of untagged analytes to modified surfaces of high-Q optical microresonators with whispering-gallery (WG) modes. Extremely small absolute amounts of bound analyte, down to 0.25 fmol of streptavidin, are detected via displacement of the resonance frequencies of the WG modes. The sensitized microresonators are dry and storable, and the flow cell sensor design lends itself to cheap, expendable fabrication.

Paper Details

Date Published: 14 February 2007
PDF: 8 pages
Proc. SPIE 6452, Laser Resonators and Beam Control IX, 64520U (14 February 2007); doi: 10.1117/12.716591
Show Author Affiliations
Ying Lin, Jet Propulsion Lab. (United States)
Vladimir Ilchenko, Jet Propulsion Lab. (United States)
Jay Nadeau, McGill Univ. (Canada)
Lute Maleki, Jet Propulsion Lab. (United States)

Published in SPIE Proceedings Vol. 6452:
Laser Resonators and Beam Control IX
Alexis V. Kudryashov; Alan H. Paxton; Vladimir S. Ilchenko, Editor(s)

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