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Proceedings Paper

Molecular imaging of photodynamic therapy efficacy
Author(s): Sung K. Chang; Nicolas Solban; Imran Rizvi; Divya Errabelli; Tayyaba Hasan
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Paper Abstract

Recent advances in light sources, detectors and other optical imaging technologies coupled with the development of novel optical contrast agents have enabled real-time, high resolution, in vivo monitoring of molecular targets. Noninvasive monitoring of molecular targets can help optimize photodynamic therapy (PDT) by providing the capabilities to monitor the efficacy of treatment. Our lab has developed optical imaging technologies to investigate a wide range of molecular, physiological and morphological responses to photodynamic therapy (PDT). With the idea that drug delivery to the different compartments in the tumor is an important determinant of the treatment effect, we studied drug delivery in vitro and in vivo using optical imaging tools. A molecular specific contrast agent that targets the vascular endothelial growth factor (VEGF) was developed to monitor the changes in the protein expression following PDT. We also studied the PDT-induced physiological changes in vascular permeability and metastasis with in vivo imaging.

Paper Details

Date Published: 14 February 2007
PDF: 6 pages
Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 644902 (14 February 2007); doi: 10.1117/12.714889
Show Author Affiliations
Sung K. Chang, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Nicolas Solban, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Imran Rizvi, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Divya Errabelli, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 6449:
Genetically Engineered and Optical Probes for Biomedical Applications IV
Samuel Achilefu; Alexander Pavlovich Savitsky; Rebekka M. Wachter; Darryl J. Bornhop; Ramesh Raghavachari, Editor(s)

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