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Proceedings Paper

Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system
Author(s): Sergey Ermilov; Alan Stein; Andre Conjusteau; Reda Gharieb; Ron Lacewell; Tom Miller; Scott Thompson; Pamela Otto; Barbara McCorvey; Tuenchit Khamapirad; Morton Leonard; Alexander Oraevsky
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Paper Abstract

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.

Paper Details

Date Published: 15 February 2007
PDF: 11 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (15 February 2007); doi: 10.1117/12.714039
Show Author Affiliations
Sergey Ermilov, Fairway Medical Technologies (United States)
Alan Stein, Seno Medical Instruments (United States)
Andre Conjusteau, Fairway Medical Technologies (United States)
Reda Gharieb, Fairway Medical Technologies (United States)
Ron Lacewell, Fairway Medical Technologies (United States)
Tom Miller, Fairway Medical Technologies (United States)
Scott Thompson, Seno Medical Instruments (United States)
Pamela Otto, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Barbara McCorvey, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Tuenchit Khamapirad, The Univ. of Texas Medical Branch at Galveston (United States)
Morton Leonard, The Univ. of Texas Medical Branch at Galveston (United States)
Alexander Oraevsky, Fairway Medical Technologies (United States)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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