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Proceedings Paper

Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source
Author(s): Andrzej Krol; Hongwei Ye; Russell Kincaid; John Boone; Marina Servol; Jean-Claude Kieffer; Yakov Nesterets; Tim Gureyev; Andrew Stevenson; Steve Wilkins; Edward Lipson; Remy Toth; Andrew Pogany; Ioana Coman
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Paper Abstract

We have investigated theoretically the mean absorbed dose to the mouse in our newly constructed, in-line holography, x-ray phase-contrast, in-vivo, micro-CT system with an ultrafast laser-based x-ray (ULX) source. We assumed that the effective mouse diameter was 30 mm and the x-ray detector required minimum 30 μGy per frame to produce high quality images. The following laser target-filter combinations were considered: Ag-Ag, Mo-Mo, Sn- Sn. In addition, we considered narrow-pass multilayer x-ray mirrors. The corresponding ULX spectra were obtained using a CZT solid-state spectrometer. The approach used for dose computation was similar to human dose estimation. The mouse was modeled as a tissue-equivalent cylinder located at the isocenter with diameter 30 mm and density 1g/cm3. A layer of dermis (skin and fur) with 1 mm thickness was also modeled. Imparted energy per volume was estimated for 1 keV wide x-ray energy intervals in the 6-100 keV range. Monte Carlo simulations were performed using the SIERRA code previously validated using 30 mm diameter PMMA phantom. The results obtained indicate that: a) the mean absorbed dose for ULX is less than or equal to that from a W-anode micro-CT tube operating at 30-40 kVp with 0.5 or 1.0 mm Al; b) for filter thickness above 100 μm, Sn-Sn results in the highest dose, followed by Ag-Ag and Mo-Mo; c) the multilayer x-ray mirror with FWHM ≤ 10 keV produces significantly lower dose than metallic foil filters. We conclude that ULX can provide better dose utilization than a microfocal x-ray tube for in vivo microtomography applications.

Paper Details

Date Published: 14 March 2007
PDF: 6 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65103P (14 March 2007); doi: 10.1117/12.713827
Show Author Affiliations
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
Hongwei Ye, Syracuse Univ. (United States)
Russell Kincaid, Syracuse Univ. (United States)
John Boone, Univ. of California Davis Medical Ctr. (United States)
Marina Servol, INRS-EMT, Univ. du Québec (Canada)
Jean-Claude Kieffer, INRS-EMT, Univ. du Québec (Canada)
Yakov Nesterets, CSIRO Manufacturing and Infrastructure Technology (Australia)
Tim Gureyev, CSIRO Manufacturing and Infrastructure Technology (Australia)
Andrew Stevenson, CSIRO Manufacturing and Infrastructure Technology (Australia)
Steve Wilkins, CSIRO Manufacturing and Infrastructure Technology (Australia)
Edward Lipson, Syracuse Univ. (United States)
Remy Toth, INRS-EMT, Univ. du Québec (Canada)
Andrew Pogany, CSIRO Manufacturing and Infrastructure Technology (Australia)
Ioana Coman, Ithaca College (United States)


Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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