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Proceedings Paper

Modulated imaging: a novel method for quantifying tissue chromophores in evolving cerebral ischemia
Author(s): David Abookasis; Marlon S. Mathews; Chistopher Lay; Ron D. Frostig; Bruce J. Tromberg
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Paper Abstract

The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.

Paper Details

Date Published: 29 March 2007
PDF: 9 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65110A (29 March 2007); doi: 10.1117/12.713470
Show Author Affiliations
David Abookasis, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Marlon S. Mathews, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Univ. of California, Irvine, Medical Ctr. (United States)
Chistopher Lay, Univ. of California, Irvine (United States)
Ron D. Frostig, Univ. of California, Irvine (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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