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Proceedings Paper

How phototherapy affects angiogenesis
Author(s): Mary Dyson
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Paper Abstract

Angiogenesis is essential for normal growth, tissue repair and regeneration. Its stimulation accelerates repair and regeneration including wound healing where these processes are delayed. Its inhibition can reduce the rate of growth of solid tumors. Phototherapy can accelerate the resolution of acute inflammation with the result that the proliferative phase of tissue repair, when angiogenesis occurs, begins earlier than in sham-irradiated controls. Evidence that angiogenesis is enhanced in dermal repair, tendon repair and bone regeneration in rodents is presented. The cellular mechanisms that control angiogenesis involve the interaction of endothelial cells, macrophages, pericytes and other cells in response, for example, to changes in the availability of oxygen in the local environment. Pericytes and macrophages modulate endothelial cell proliferation; pericytes guide endothelial cell migration. The stimulation of endothelial cell proliferation in vitro following exposure to red (660 nm) and infrared (820 nm) radiation, 15 mW, at 2-8 J/cm2 is presented. 1J/cm2 was ineffective. 820 nm irradiation, 15 mW, at 8 J/cm2 was observed to inhibit pericyte proliferation in vitro. Indirect effects on endothelial cell and pericyte proliferation followed stimulation of soluble mediator production by macrophages following exposure to red and infrared radiation. The potential clinical significance of the results obtained is discussed and the necessity of clinical trials emphasized.

Paper Details

Date Published: 21 February 2007
PDF: 3 pages
Proc. SPIE 6428, Mechanisms for Low-Light Therapy II, 642808 (21 February 2007); doi: 10.1117/12.713180
Show Author Affiliations
Mary Dyson, Kings College London (United Kingdom)

Published in SPIE Proceedings Vol. 6428:
Mechanisms for Low-Light Therapy II
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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