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Proceedings Paper

Intelligent spectral signature bio-imaging in vivo for surgical applications
Author(s): Jihoon Jeong; Philip K. Frykman; Mark Gaon; Alice P. Chung; Erik H. Lindsley; Jae Y. Hwang; Daniel L. Farkas
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Paper Abstract

Multi-spectral imaging provides digital images of a scene or object at a large, usually sequential number of wavelengths, generating precise optical spectra at every pixel. We use the term "spectral signature" for a quantitative plot of optical property variations as a function of wavelengths. We present here intelligent spectral signature bio-imaging methods we developed, including automatic signature selection based on machine learning algorithms and database search-based automatic color allocations, and selected visualization schemes matching these approaches. Using this intelligent spectral signature bio-imaging method, we could discriminate normal and aganglionic colon tissue of the Hirschsprung's disease mouse model with over 95% sensitivity and specificity in various similarity measure methods and various anatomic organs such as parathyroid gland, thyroid gland and pre-tracheal fat in dissected neck of the rat in vivo.

Paper Details

Date Published: 19 February 2007
PDF: 8 pages
Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411N (19 February 2007); doi: 10.1117/12.712412
Show Author Affiliations
Jihoon Jeong, Univ. of Southern California, Los Angeles (United States)
Cedars-Sinai Medical Ctr. (United States)
Philip K. Frykman, Cedars-Sinai Medical Ctr. (United States)
Mark Gaon, Cedars-Sinai Medical Ctr. (United States)
Alice P. Chung, Cedars-Sinai Medical Ctr. (United States)
Erik H. Lindsley, Cedars-Sinai Medical Ctr. (United States)
Jae Y. Hwang, Univ. of Southern California, Los Angeles (United States)
Cedars-Sinai Medical Ctr. (United States)
Daniel L. Farkas, Univ. of Southern California, Los Angeles (United States)
Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 6441:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
Daniel L. Farkas; Robert C. Leif; Dan V. Nicolau, Editor(s)

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