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Proceedings Paper

Integrated visualization of multi-angle bioluminescence imaging and micro CT
Author(s): P. Kok; J. Dijkstra; C. P. Botha; F. H. Post; E. Kaijzel; I. Que; C. W. G. M. Löwik; J. H. C. Reiber; B. P. F. Lelieveldt
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Paper Abstract

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

Paper Details

Date Published: 22 March 2007
PDF: 10 pages
Proc. SPIE 6509, Medical Imaging 2007: Visualization and Image-Guided Procedures, 65091U (22 March 2007); doi: 10.1117/12.711117
Show Author Affiliations
P. Kok, Leiden Univ. Medical Ctr. (Netherlands)
Delft Univ. of Technology (Netherlands)
J. Dijkstra, Leiden Univ. Medical Ctr. (Netherlands)
C. P. Botha, Leiden Univ. Medical Ctr. (Netherlands)
Delft Univ. of Technology (Netherlands)
F. H. Post, Delft Univ. of Technology (Netherlands)
E. Kaijzel, Leiden Univ. Medical Ctr. (Netherlands)
I. Que, Leiden Univ. Medical Ctr. (Netherlands)
C. W. G. M. Löwik, Leiden Univ. Medical Ctr. (Netherlands)
J. H. C. Reiber, Leiden Univ. Medical Ctr. (Netherlands)
B. P. F. Lelieveldt, Leiden Univ. Medical Ctr. (Netherlands)


Published in SPIE Proceedings Vol. 6509:
Medical Imaging 2007: Visualization and Image-Guided Procedures
Kevin R. Cleary; Michael I. Miga, Editor(s)

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