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Proceedings Paper

Cell cycle dependence of protophorphyrin IX generation in 9L rat gliosarcoma
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Paper Abstract

Photodynamic therapy (PDT) is a cancer therapy that utilizes optical energy to activate a photosensitizer drug in a target tissue. Always, the curative effect is dependent on the light fluence, the concentration of the photosensitizer and the concentration of the oxygen. To date, Protophorphyrin IX (PpIX) as the only one endogenous photosensitizer is widely used in PDT of brain tumors. Since PpIX is synthesized in intracellular structure, and is likely dependent on the phase of the cell cycle. The cell cycle dependence of PpIX production is thus investigated in the current work in 9L gliosarcoma cells.

Paper Details

Date Published: 27 October 2006
PDF: 4 pages
Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 60473A (27 October 2006); doi: 10.1117/12.710931
Show Author Affiliations
Shiming Luo, South China Normal Univ. (China)
Xing Da, South China Normal Univ. (China)
Qun Chen, South China Normal Univ. (China)
HealthONE Alliance (United States)


Published in SPIE Proceedings Vol. 6047:
Fourth International Conference on Photonics and Imaging in Biology and Medicine
Kexin Xu; Qingming Luo; Da Xing; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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