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Proceedings Paper

Expresssion of bax/bcl-xl by low-power laser irradiation in the Amyloid Beta 25-35 induced apoptosis of PC12 cell
Author(s): Lan Zhang; Da Xing
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Paper Abstract

Apoptosis has been reported as a contributing pathophysiological mechanism of Alzheimer's disease (AD). Recently, the anti-apoptosis function of low-power laser irradiation (LPLI) was proposed, suggesting LPLI may become a new means for AD therapy. In this study, we aimed to demonstrate the anti-apoptosis function of LPLI at molecular level. Aβ25-35 was used to induce apoptosis of PC12 cell, and then the cells were dealt with LPLI. After irradiation, the molecular level of apoptosis was detected by quantifying the bax I bcl-xl mRNA ratio using a highly sensitive and quantitative polymerase chain reaction (QT-PCR) technique. The primary results show that the bax Ibcl-xl mRNA ratio of the PC12 cell treated with Aβ25-35 was decreased by LPLI, demonstrating the anti-apoptosis function of LPLI at molecular level.

Paper Details

Date Published: 27 October 2006
PDF: 6 pages
Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 60473E (27 October 2006); doi: 10.1117/12.710708
Show Author Affiliations
Lan Zhang, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 6047:
Fourth International Conference on Photonics and Imaging in Biology and Medicine
Kexin Xu; Qingming Luo; Da Xing; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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