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Proceedings Paper

Design and evaluation of a portable continuous-wave NIR topography instrument
Author(s): Yi Zheng; Zhili Zhang; Qian Liu; Chuanhua Cao; Hui Gong
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Paper Abstract

Near Infrared Spectroscopy (NIRS) has been widely used to access the brain functional activity non-invasively. A portable, multi-channel, continuous-wave (CW) NIR topography instrument we designed to measure the concentration changes of each hemoglobin species and map cerebral cortex functional activation. The probe of instrument consists of 4 LEDs operating at three-wavelength (735 nm & 805 nm & 850 nm) surrounded with 10 photodiodes mounted on a flexible PCB with the interoptode distance up to 2.88cm. On the basis of the modified Beer-Lambert law, the ratios of optical density changes in a ftilly oxygenated and deoxygenated state are determined by varying blood volume and hemoglobin oxygenation state in model experiment. The average ratios are 0.56. 1.74 and 0.45. Additionally, study on the phantoms is carried out to investigate the penetration depth (13 mm) of the sensor array.

Paper Details

Date Published: 27 October 2006
PDF: 7 pages
Proc. SPIE 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine, 60470X (27 October 2006); doi: 10.1117/12.710686
Show Author Affiliations
Yi Zheng, Key Lab. of Biomedical Photonics of Ministry of Education (China)
Zhili Zhang, Key Lab. of Biomedical Photonics of Ministry of Education (China)
Qian Liu, Key Lab. of Biomedical Photonics of Ministry of Education (China)
Hubei Bioinformatics and Molecular Imaging Key Lab., Huazhong Univ. of Science and Technology (China)
Chuanhua Cao, Hubei Bioinformatics and Molecular Imaging Key Lab., Huazhong Univ. of Science and Technology (China)
Hui Gong, Key Lab. of Biomedical Photonics of Ministry of Education (China)
Hubei Bioinformatics and Molecular Imaging Key Lab., Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6047:
Fourth International Conference on Photonics and Imaging in Biology and Medicine
Kexin Xu; Qingming Luo; Da Xing; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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