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Proceedings Paper

Automated localization of periventricular and subcortical white matter lesions
Author(s): Fedde van der Lijn; Meike W. Vernooij; M. Arfan Ikram; Henri A. Vrooman; Daniel Rueckert; Alexander Hammers; Monique M. B. Breteler; Wiro J. Niessen
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Paper Abstract

It is still unclear whether periventricular and subcortical white matter lesions (WMLs) differ in etiology or clinical consequences. Studies addressing this issue would benefit from automated segmentation and localization of WMLs. Several papers have been published on WML segmentation in MR images. Automated localization however, has not been investigated as much. This work presents and evaluates a novel method to label segmented WMLs as periventricular and subcortical. The proposed technique combines tissue classification and registration-based segmentation to outline the ventricles in MRI brain data. The segmented lesions can then be labeled into periventricular WMLs and subcortical WMLs by applying region growing and morphological operations. The technique was tested on scans of 20 elderly subjects in which neuro-anatomy experts manually segmented WMLs. Localization accuracy was evaluated by comparing the results of the automated method with a manual localization. Similarity indices and volumetric intraclass correlations between the automated and the manual localization were 0.89 and 0.95 for periventricular WMLs and 0.64 and 0.89 for subcortical WMLs, respectively. We conclude that this automated method for WML localization performs well to excellent in comparison to the gold standard.

Paper Details

Date Published: 26 March 2007
PDF: 8 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 651232 (26 March 2007); doi: 10.1117/12.710532
Show Author Affiliations
Fedde van der Lijn, Erasmus Medical Ctr. (Netherlands)
Meike W. Vernooij, Erasmus Medical Ctr. (Netherlands)
M. Arfan Ikram, Erasmus Medical Ctr. (Netherlands)
Henri A. Vrooman, Erasmus Medical Ctr. (Netherlands)
Daniel Rueckert, Imperial College London (United Kingdom)
Alexander Hammers, Imperial College at Hammersmith Hospital (United Kingdom)
Monique M. B. Breteler, Erasmus Medical Ctr. (Netherlands)
Wiro J. Niessen, Erasmus Medical Ctr. (Netherlands)


Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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