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Proceedings Paper

Multiscale fuzzy C-means image classification for multiple weighted MR images for the assessment of photodynamic therapy in mice
Author(s): Hesheng Wang; Denise Feyes; John Mulvihill; Nancy Oleinick; Gregory MacLennan; Baowei Fei
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Paper Abstract

We are investigating in vivo small animal imaging and analysis methods for the assessment of photodynamic therapy (PDT), an emerging therapeutic modality for cancer treatment. Multiple weighted MR images were acquired from tumor-bearing mice pre- and post-PDT and 24-hour after PDT. We developed an automatic image classification method to differentiate live, necrotic and intermediate tissues within the treated tumor on the MR images. We used a multiscale diffusion filter to process the MR images before classification. A multiscale fuzzy C-means (FCM) classification method was applied along the scales. The object function of the standard FCM was modified to allow multiscale classification processing where the result from a coarse scale is used to supervise the classification in the next scale. The multiscale fuzzy C-means (MFCM) method takes noise levels and partial volume effects into the classification processing. The method was validated by simulated MR images with various noise levels. For simulated data, the classification method achieved 96.0 ± 1.1% overlap ratio. For real mouse MR images, the classification results of the treated tumors were validated by histologic images. The overlap ratios were 85.6 ± 5.1%, 82.4 ± 7.8% and 80.5 ± 10.2% for the live, necrotic, and intermediate tissues, respectively. The MR imaging and the MFCM classification methods may provide a useful tool for the assessment of the tumor response to photodynamic therapy in vivo.

Paper Details

Date Published: 8 March 2007
PDF: 9 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65122W (8 March 2007); doi: 10.1117/12.710188
Show Author Affiliations
Hesheng Wang, Case Western Reserve Univ. (United States)
Denise Feyes, Case Western Reserve Univ. (United States)
John Mulvihill, Case Western Reserve Univ. (United States)
Nancy Oleinick, Case Western Reserve Univ. (United States)
Gregory MacLennan, Case Western Reserve Univ. (United States)
Baowei Fei, Case Western Reserve Univ. (United States)

Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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