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Proceedings Paper

Bolus tracking by cone-beam reconstruction and reprojection
Author(s): Zikuan Chen; Ruola Ning
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Paper Abstract

Contrast agent bolus is used in angiography for vascular imaging. The bolus flow through a local region in the bolus wash-in phase can be captured by cone-beam scanning, producing a time series of projection images. During the bolus/blood equilibrium phase, circular cone-beam volume scanning produces a dataset that can be used for vessel (or bolus) volume reconstruction. From a bolus (or vessel) volume, we can depict the vessel anatomy and extract the 3D bolus passageways. For bolus velocity measurements, we need to calculate the 3D bolus pathlength and to determine the time interval indicated by the frame time of the dynamic bolus wash-in images. The cone-beam volume reconstruction allows 3D vessel depiction with isotropic grid resolution, thus facilitating the measurement of 3D vessel lumen and centerline. The timing information of the dynamic bolus flow corresponds to the frame time of the bolus wash-in images. In order to add time divisions to a 3D bolus passageway, we suggest a cone-beam reprojection scheme, which consists of vessel-centerline extraction, cone-beam reprojection, and image registration between reprojected images and wash-in projection images. With the accurate measurements of 3D pathlength and time interval, we can calculate the local blood flow in terms of velocity and flux. Simulations of bolus traveling along a sinuate vessel inside a cylinder are provided.

Paper Details

Date Published: 29 March 2007
PDF: 12 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111Z (29 March 2007); doi: 10.1117/12.710132
Show Author Affiliations
Zikuan Chen, Northeastern Univ. (China)
Ruola Ning, Univ. of Rochester (United States)

Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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