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Proceedings Paper

Brain shift analysis for deep brain stimulation surgery using non-rigid registration
Author(s): Muhammad F. Khan; Klaus Mewes; Robert Gross; Oskar Škrinjar
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Paper Abstract

Deep brain stimulation (DBS) surgery is a treatment for patients suffering from Parkinson's disease and other movement disorders. The success of the procedure depends on the implantation accuracy of the DBS electrode array. Surgical planning and navigation are done based on the pre-operative patient scans, assuming that brain tissues do not move from the time of the pre-operative image acquisition to the time of the surgery. We performed brain shift analysis on nine patients that underwent DBS surgery using a 3D non-rigid registration algorithm. The registration algorithm automatically aligns the pre-operative and the post-operative 3D MRI scans and provides the shift vectors over the entire brain. The images were first aligned rigidly and then non-rigidly registered with an algorithm based on thin plate splines and maximization of the normalized mutual information. Brain shift of up to 8 mm was recorded in the nine subjects, which is significant given that the size of the targets in the DBS surgery is a few millimeters.

Paper Details

Date Published: 21 March 2007
PDF: 9 pages
Proc. SPIE 6509, Medical Imaging 2007: Visualization and Image-Guided Procedures, 65091B (21 March 2007); doi: 10.1117/12.710009
Show Author Affiliations
Muhammad F. Khan, Georgia Institute of Technology (United States)
Klaus Mewes, Emory Univ. (United States)
Robert Gross, Emory Univ. (United States)
Oskar Škrinjar, Georgia Institute of Technology (United States)


Published in SPIE Proceedings Vol. 6509:
Medical Imaging 2007: Visualization and Image-Guided Procedures
Kevin R. Cleary; Michael I. Miga, Editor(s)

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