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Proceedings Paper

Solid component evaluation in mixed ground glass nodules
Author(s): Benjamin L. Odry; Jing Huo; Li Zhang; Carol L. Novak; David P. Naidich
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Paper Abstract

Multi-Slice Computed Tomography (MSCT) imaging of the lungs allow for detection and follow-up of very small lesions including solid and ground glass nodules (GGNs). However relatively few computer-based methods have been implemented for GGN segmentation. GGNs can be divided into pure GGNs and mixed GGNs, which contain both nonsolid and solid components (SC). This latter category is especially of interest since some studies indicate a higher likelihood of malignancy in GGNs with SC. Due to their characteristically slow growth rate, GGNs are typically monitored with multiple follow-up scans, making measurement of the volume of both solid and non-solid component especially desirable. We have developed an automated method to estimate the SC percentage within a segmented GGN. First, the SC algorithm uses a novel method to segment out the solid structures, while excluding any vessels passing near or through the nodule. A gradient distribution analysis around solid structures validates the presence or absence of SC. We tested 50 GGNs, split between three groups: 15 GGNs with SC, 15 GGNs with a solid nodule added to simulate SC, and 20 GGNs without SC. With three defined satisfaction levels for the segmentation (A: succeed, B: acceptable, C: failed), the first group resulted in 60% with score A, 40% with score B, 0% with score C. The second group resulted in 66.7% with score A and 33.3% with score B. In testing the first and 3rd groups, the algorithm correctly detected SC in all cases where it was present (sensitivity of 100%) and correctly determined absence of SC in 15 out of 20 cases (specificity 75%).

Paper Details

Date Published: 26 March 2007
PDF: 9 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65120R (26 March 2007); doi: 10.1117/12.709892
Show Author Affiliations
Benjamin L. Odry, Siemens Corporate Research Inc. (United States)
Jing Huo, Univ. of California Los Angeles (United States)
Li Zhang, Siemens Corporate Research Inc. (United States)
Carol L. Novak, Siemens Corporate Research Inc. (United States)
David P. Naidich, New York Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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