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Proceedings Paper

A knowledge-guided active model method of skull segmentation on T1-weighted MR images
Author(s): Zuyao Y. Shan; Chia-Ho Hua; Qing Ji; Carlos Parra; Xiaofei Ying; Matthew J. Krasin; Thomas E. Merchant; Larry E. Kun; Wilburn E. Reddick
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Paper Abstract

Skull is the anatomic landmark for patient set up of head radiation therapy. Skull is generally segmented from CT images because CT provides better definition of skull than MR imaging. In the mean time, radiation therapy is planned on MR images for soft tissue information. This study utilized a knowledge-guided active model (KAM) method to segmented skull on MR images in order to enable radiation therapy planning with MR images as the primary planning dataset. KAM utilized age-specific skull mesh models that segmented from CT images using a conditional region growing algorithm. Skull models were transformed to given MR images using an affine registration algorithm based on normalized mutual information. The transformed mesh models actively located skull boundaries by minimizing their total energy. The preliminary validation was performed on MR and CT images from five patients. The KAM segmented skulls were compared with those segmented from CT images. The average image similarity (kappa index) was 0.57. The initial validation showed that it was promising to segment skulls directly on MR images using KAM.

Paper Details

Date Published: 8 March 2007
PDF: 6 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65122R (8 March 2007); doi: 10.1117/12.709801
Show Author Affiliations
Zuyao Y. Shan, St. Jude Children's Research Hospital (United States)
Chia-Ho Hua, St. Jude Children's Research Hospital (United States)
Qing Ji, St. Jude Children's Research Hospital (United States)
Carlos Parra, St. Jude Children's Research Hospital (United States)
Xiaofei Ying, St. Jude Children's Research Hospital (United States)
Matthew J. Krasin, St. Jude Children's Research Hospital (United States)
Thomas E. Merchant, St. Jude Children's Research Hospital (United States)
Larry E. Kun, St. Jude Children's Research Hospital (United States)
Wilburn E. Reddick, St. Jude Children's Research Hospital (United States)


Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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