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Proceedings Paper

In vivo-CT system with respiratory and cardiac gating using synchrotron radiation
Author(s): Toshihiro Sera; Hideo Yokota; Kazuhiro Fujisaki; Kazuaki Fukasaku; Kentaro Uesugi; Naoto Yagi; Ryutaro Himeno
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Paper Abstract

The interest in using small animal models of human disease has produced a need to design a CT system at a microscopic level comparable to that achievable in a clinical CT in human. In this study, we developed a high-resolution in vivo-CT system with respiratory and cardiac gating using synchrotron radiation. The system was constructed in BL20B2 at SPring-8. SPring-8 is the third generation synchrotron radiation source in Hyogo, Japan, and prefers much higher flux X-ray than a laboratory X-ray source. Another advantage of synchrotron monochromatic CT is the minimalization of beam hardening effects, which pose serious problems when using white X-rays. Since the X-ray beam from the synchrotron source is parallel, each horizontal line corresponds to a slice position along the rotation axis. Multiple slices are easily obtained in one rotation (3D-CT). For in vivo scanning, the X-ray mechanical shutter and CCD electrical shutter were synchronized with an airway pressure (respiratory) and electrocardiographic (ECG) signal. Synchronization reduced the motion artifacts caused by respiration and heart beats, markedly improving visualization of the edges of the heart, ribs and diaphragm. In particular, small airways (diameter > 300 &mgr;m) and cerebral blood vessels were visualized clearly. This system is very useful for evaluating lung physiology and cardiovascular mechanics in vivo.

Paper Details

Date Published: 29 March 2007
PDF: 9 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 651103 (29 March 2007); doi: 10.1117/12.709619
Show Author Affiliations
Toshihiro Sera, RIKEN-The Institute of Physical and Chemical Research (Japan)
Japan Synchrotron Radiation Research Institute (Japan)
Hideo Yokota, RIKEN-The Institute of Physical and Chemical Research (Japan)
Kazuhiro Fujisaki, RIKEN-The Institute of Physical and Chemical Research (Japan)
Kazuaki Fukasaku, RIKEN-The Institute of Physical and Chemical Research (Japan)
Kentaro Uesugi, Japan Synchrotron Radiation Research Institute (Japan)
Naoto Yagi, Japan Synchrotron Radiation Research Institute (Japan)
Ryutaro Himeno, RIKEN-The Institute of Physical and Chemical Research (Japan)


Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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