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Proceedings Paper

Implementation of a fully 3D system model for brain SPECT with fan-beam-collimator OSEM reconstruction with 3D total variation regularization
Author(s): Hongwei Ye; Andrzej Krol; Edward D. Lipson; Yao Lu; Yuesheng Xu; Wei Lee; David H. Feiglin
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Paper Abstract

In order to improve tomographically reconstructed image quality, we have implemented a fully 3D reconstruction, using an ordered subsets expectation maximization (OSEM) algorithm for fan-beam collimator (FBC) SPECT, along with a volumetric system model-fan-volume system model (FVSM), a modified attenuation compensation, a 3D depth- and angle-dependent resolution and sensitivity correction, and a 3D total variation (TV) regularization. SPECT data were acquired in a 128x64 matrix, in 120 views with a circular orbit. The numerical Zubal brain phantom was used to simulate a FBC HMPAO Tc-99m brain SPECT scan, and a low noise and scatter-free projection dataset was obtained using the SimSET Monte Carlo package. A SPECT scan for a mini-Defrise phantom and brain HMPAO SPECT scans for five patients were acquired with a triple-head gamma camera (Triad 88) equipped with a low-energy high-resolution (LEHR) FBC. The reconstructed images, obtained using clinical filtered back projection (FBP), OSEM with a line-length system model (LLSM) and 3D TV regularization, and OSEM with FVSM and 3D TV regularization were quantitatively studied. Overall improvement in the image quality has been observed, including better axial and transaxial resolution, better integral uniformity, higher contrast-to-noise ration between the gray matter and the white matter, and better accuracy and lower bias in OSEM-FVSM, compared with OSEM-LLSM and clinical FBP.

Paper Details

Date Published: 16 March 2007
PDF: 6 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65104T (16 March 2007); doi: 10.1117/12.709560
Show Author Affiliations
Hongwei Ye, Syracuse Univ. (United States)
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
Edward D. Lipson, Syracuse Univ. (United States)
SUNY Upstate Medical Univ. (United States)
Yao Lu, Syracuse Univ. (United States)
Yuesheng Xu, Syracuse Univ. (United States)
Wei Lee, SUNY Upstate Medical Univ. (United States)
David H. Feiglin, SUNY Upstate Medical Univ. (United States)


Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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