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Proceedings Paper

Qualitative comparison of intra-aneurysmal flow structures determined from conventional and virtual angiograms
Author(s): Juan R. Cebral; Alessandro Radaelli; Alejandro Frangi; Christopher M. Putman
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Paper Abstract

In this study we qualitatively compare the flow structures observed in cerebral aneurysms using conventional angiography and virtual angiograms produced from patient-specific computational fluid dynamics (CFD) models. For this purpose, high frame rate biplane angiograms were obtained during a rapid injection of contrast agent in three patients with intracranial aneurysms. Patient-specific CFD models were then constructed from 3D rotational angiography images of each aneurysm. Time dependent flow fields were obtained from the numerical solution of the incompressible Navier-Stokes equations under pulsatile flow conditions derived from phase-contrast magnetic resonance measurements performed on normal subjects. These flow fields were subsequently used to simulate the transport of a contrast agent by solving the advection-diffusion equation. Both the fluid and transport equations were solved with an implicit finite element formulation on unstructured grids. Virtual angiograms were then constructed by volume rendering of the simulated dye concentration field. The flow structures observed in the conventional and virtual angiograms were then qualitatively compared. It was found that the finite element models showed distinct flow types for each aneurysm, ranging from simple to complex. The virtual angiograms showed good agreement with the images from the conventional angiograms for all three aneurysms. Analogous size and orientation of the inflow jet, regions of flow impaction, major intraaneurysmal vortices and regions of outflow were observed in both the conventional and virtual angiograms. In conclusion, patient-specific image-based computational models of intracranial aneurysms can realistically reproduce the major intraaneurysmal flow structures observed with conventional angiography.

Paper Details

Date Published: 29 March 2007
PDF: 9 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111E (29 March 2007); doi: 10.1117/12.709231
Show Author Affiliations
Juan R. Cebral, George Mason Univ. (United States)
Alessandro Radaelli, Pompeu Fabra Univ. (Spain)
Alejandro Frangi, Pompeu Fabra Univ. (Spain)
Christopher M. Putman, Inova Fairfax Hospital (United States)


Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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