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Proceedings Paper

Analysis of trabecular bone architectural changes induced by osteoarthritis in rabbit femur using 3D active shape model and digital topology
Author(s): P. K. Saha; C. S. Rajapakse; D. S. Williams; L. Duong; A. Coimbra
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Paper Abstract

Osteoarthritis (OA) is the most common chronic joint disease, which causes the cartilage between the bone joints to wear away, leading to pain and stiffness. Currently, progression of OA is monitored by measuring joint space width using x-ray or cartilage volume using MRI. However, OA affects all periarticular tissues, including cartilage and bone. It has been shown previously that in animal models of OA, trabecular bone (TB) architecture is particularly affected. Furthermore, relative changes in architecture are dependent on the depth of the TB region with respect to the bone surface and main direction of load on the bone. The purpose of this study was to develop a new method for accurately evaluating 3D architectural changes induced by OA in TB. Determining the TB test domain that represents the same anatomic region across different animals is crucial for studying disease etiology, progression and response to therapy. It also represents a major technical challenge in analyzing architectural changes. Here, we solve this problem using a new active shape model (ASM)-based approach. A new and effective semi-automatic landmark selection approach has been developed for rabbit distal femur surface that can easily be adopted for many other anatomical regions. It has been observed that, on average, a trained operator can complete the user interaction part of landmark specification process in less than 15 minutes for each bone data set. Digital topological analysis and fuzzy distance transform derived parameters are used for quantifying TB architecture. The method has been applied on micro-CT data of excised rabbit femur joints from anterior cruciate ligament transected (ACLT) (n = 6) and sham (n = 9) operated groups collected at two and two-to-eight week post-surgery, respectively. An ASM of the rabbit right distal femur has been generated from the sham group micro-CT data. The results suggest that, in conjunction with ASM, digital topological parameters are suitable for analyzing architectural changes induced by OA.

Paper Details

Date Published: 29 March 2007
PDF: 12 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65110J (29 March 2007); doi: 10.1117/12.709064
Show Author Affiliations
P. K. Saha, The Univ. of Iowa (United States)
C. S. Rajapakse, Univ. of Pennsylvania (United States)
D. S. Williams, Merck Research Labs. (United States)
L. Duong, Merck Research Labs. (United States)
A. Coimbra, Merck Research Labs. (United States)

Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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