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Proceedings Paper

The functional connectivity of semantic task changes in the recovery from stroke aphasia
Author(s): Jie Lu; Xia Wu; Li Yao; Kun-Cheng Li; Hua Shu; Qi Dong
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Paper Abstract

Little is known about the difference of functional connectivity of semantic task between the recovery aphasic patients and normal subject. In this paper, an fMRI experiment was performed in a patient with aphasia following a left-sided ischemic lesion and normal subject. Picture naming was used as semantic activation task in this study. We compared the preliminary functional connectivity results of the recovery aphasic patient with the normal subject. The fMRI data were separated by independent component analysis (ICA) into 90 components. According to our experience and other papers, we chose a region of interest (ROI) of semantic (x=-57, y=15, z=8, r=11mm). From the 90 components, we chose one component as the functional connectivity of the semantic ROI according to one criterion. The criterion is the mean value of the voxels in the ROI. So the component of the highest mean value of the ROI is the functional connectivity of the ROI. The voxel with its value higher than 2.4 was thought as activated (p<0.05). And the functional connectivity networks of the normal subjects were t-tested as group network. From the result, we can know the semantic functional connectivity of stroke aphasic patient and normal subjects are different. The activated areas of the left inferior frontal gyrus and inferior/middle temporal gyrus are larger than the ones of normal. The activated area of the right inferior frontal gyrus is smaller than the ones of normal. The functional connectivity of stroke aphasic patient under semantic condition is different with the normal one. The focus of the stroke aphasic patient can affect the functional connectivity.

Paper Details

Date Published: 29 March 2007
PDF: 8 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 651122 (29 March 2007); doi: 10.1117/12.709034
Show Author Affiliations
Jie Lu, Beijing Normal Univ. (China)
Xuanwu Hospital, Capital Medical Univ. (China)
Xia Wu, Beijing Normal Univ. (China)
Li Yao, Beijing Normal Univ. (China)
Kun-Cheng Li, Xuanwu Hospital, Capital Medical Univ. (China)
Hua Shu, Beijing Normal Univ. (China)
Qi Dong, Beijing Normal Univ. (China)


Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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