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Proceedings Paper

Combined clinical and computational information in complex cerebral aneurysms: application to mirror cerebral aneurysms
Author(s): Alessandro G. Radaelli; Teresa Sola Martínez; Elio Vivas Díaz; Xavier Mellado; Marcelo A. Castro; Christopher M. Putman; Leopoldo Guimaraens; Juan R. Cebral; Alejandro F. Frangi
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Paper Abstract

Although the incidence of ruptured cerebral aneurysms is relatively small, when rupture occurs, morbidity and mortality are exceptionally high. The understanding of the pathological and physiological forces driving aneurysmal pathogenesis and progression is crucial. In this paper we analyze the occurrence of mirror cerebral aneurysms in 8 patients and speculate on the effect of haemodynamics on the localization and course of the disease. By mirror cerebral aneurysms we indicate two aneurysms in the same patient and at the same location in the cerebral vasculature but symmetrically with respect to a sagittal plane. In particular we focus on cases of mirror cerebral aneurysms where only one of the two aneurysms presented subarachnoid hemorrhage (SAH). Anatomical information is extracted from 3D rotational angiography (3DRA) images and haemodynamic information is obtained through blood flow simulation in patientspecific anatomical models. The distribution of Wall Shear Stress (WSS) and the flow patterns through the vessels and inside the aneurysms are reported. By combining clinical observations on asymmetry of the cerebral vasculature and aneurysmal shape and size with computed information on blood flow patterns we explore the causes behind a specific localization and a different outcome of disease progression.

Paper Details

Date Published: 29 March 2007
PDF: 12 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111F (29 March 2007); doi: 10.1117/12.708955
Show Author Affiliations
Alessandro G. Radaelli, Pompeu Fabra Univ. (Spain)
Teresa Sola Martínez, Hospital General de Catalunya (Spain)
Elio Vivas Díaz, Hospital General de Catalunya (Spain)
Xavier Mellado, Pompeu Fabra Univ. (Spain)
Marcelo A. Castro, George Mason Univ. (United States)
Christopher M. Putman, Inova Fairfax Hospital (United States)
Leopoldo Guimaraens, Hospital General de Catalunya (Spain)
Juan R. Cebral, George Mason Univ. (United States)
Alejandro F. Frangi, Pompeu Fabra Univ. (Spain)


Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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