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Proceedings Paper

Water-soluble (MUA-coated) quantum dots: physicochemical characterization and application
Author(s): Chih-Hui Yang; Keng-Shiang Huang; Sheng-Ji Lee; Kuo-Chin Lin; Yu-Cheng Lin
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Paper Abstract

This paper described the physicochemical characterization and application of quantum dots (CdSe/ZnS, QDs) whose surface were hydrophilic modified by mercaptoundecanoic acid (MUA). The stability kinetics of MUA-coated QDs (MUA-QDs) in aqueous solution was studied as a function of MUA-QDs concentration, type of light exposed, pH conditions and temperatures. The results show that the optimum concentration range of MUA-QDs is 0.5 to 1 mg/mL. We found that no obvious difference of fluorescence intensity was detected in MUA-QDs stored respectively at 4°C, 24°C and 44°C (8-hour). When they were exposed to UV light (312 nm) for 8 hr, their fluorescence intensity was shown serious decay. Moreover, the results showed that the pH of maximum stability of MUA-QDs in buffer solutions was 8. Finally, MUA-QDs had been endocytosis into H9c2 cells, a permanent cell line derived from rat cardiac tissue, for cell imaging application, the results provided the benefit to apply MUA-QDs in medical areas.

Paper Details

Date Published: 22 January 2007
PDF: 6 pages
Proc. SPIE 6465, Microfluidics, BioMEMS, and Medical Microsystems V, 64650L (22 January 2007); doi: 10.1117/12.708787
Show Author Affiliations
Chih-Hui Yang, I-Shou Univ. (Taiwan)
Keng-Shiang Huang, National Cheng Kung Univ. (Taiwan)
Sheng-Ji Lee, National Cheng Kung Univ. (Taiwan)
Kuo-Chin Lin, National Cheng Kung Univ. (Taiwan)
Yu-Cheng Lin, National Cheng Kung Univ. (Taiwan)


Published in SPIE Proceedings Vol. 6465:
Microfluidics, BioMEMS, and Medical Microsystems V
Ian Papautsky; Wanjun Wang, Editor(s)

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