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Proceedings Paper

Interferometric optical online dosimetry for selective retina treatment (SRT)
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Paper Abstract

In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.

Paper Details

Date Published: 5 March 2007
PDF: 7 pages
Proc. SPIE 6426, Ophthalmic Technologies XVII, 642619 (5 March 2007); doi: 10.1117/12.708521
Show Author Affiliations
Hardo Stoehr, Univ. of Lübeck (Germany)
Lars Ptaszynski, Univ. of Lübeck (Germany)
Andreas Fritz, Univ. of Lübeck (Germany)
Ralf Brinkmann, Univ. of Lübeck (Germany)

Published in SPIE Proceedings Vol. 6426:
Ophthalmic Technologies XVII
Bruce E. Stuck; Fabrice Manns; Per G. Söderberg; Michael Belkin; Arthur Ho, Editor(s)

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