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Proceedings Paper

Quantifying brain development in early childhood using segmentation and registration
Author(s): P. Aljabar; K. K. Bhatia; M. Murgasova; J. V. Hajnal; J. P. Boardman; L. Srinivasan; M. A. Rutherford; L. E. Dyet; A. D. Edwards; D. Rueckert
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Paper Abstract

In this work we obtain estimates of tissue growth using longitudinal data comprising MR brain images of 25 preterm children scanned at one and two years. The growth estimates are obtained using segmentation and registration based methods. The segmentation approach used an expectation maximisation (EM) method to classify tissue types and the registration approach used tensor based morphometry (TBM) applied to a free form deformation (FFD) model. The two methods show very good agreement indicating that the registration and segmentation approaches can be used interchangeably. The advantage of the registration based method, however, is that it can provide more local estimates of tissue growth. This is the first longitudinal study of growth in early childhood, previous longitudinal studies have focused on later periods during childhood.

Paper Details

Date Published: 26 March 2007
PDF: 8 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65120O (26 March 2007); doi: 10.1117/12.706508
Show Author Affiliations
P. Aljabar, Imperial College London (United Kingdom)
K. K. Bhatia, Imperial College London (United Kingdom)
M. Murgasova, Imperial College London (United Kingdom)
J. V. Hajnal, Imperial College London, Hammersmith Hospital (United Kingdom)
J. P. Boardman, Imperial College London, Hammersmith Hospital (United Kingdom)
Imperial College London, and MRC Clinical Sciences Ctr., Hammersmith Hospital (United Kingdom)
L. Srinivasan, Imperial College London (United Kingdom)
Imperial College London, and MRC Clinical Sciences Ctr., Hammersmith Hospital (United Kingdom)
M. A. Rutherford, Imperial College London (United Kingdom)
Imperial College London, and MRC Clinical Sciences Ctr., Hammersmith Hospital (United Kingdom)
L. E. Dyet, Imperial College London, Hammersmith Hospital (United Kingdom)
Imperial College London, and MRC Clinical Sciences Ctr., Hammersmith Hospital (United Kingdom)
A. D. Edwards, Imperial College London, Hammersmith Hospital (United Kingdom)
MRC Clinical Sciences Ctr., Hammersmith Hospital (United Kingdom)
D. Rueckert, Imperial College London (United Kingdom)


Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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