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Proceedings Paper

Clinical pharmacokinetics of protoporphyrin IX (PpIX) in condylomata acuminata patients: ex vivo fluorescence examination
Author(s): Xiu-Li Wang; Hong-Wei Wang; Zheng Huang; Herbert Stepp; Reinhold Baumgartner; Christian Dannecker; Peter Hillemanns
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Paper Abstract

Objectives: To investigate the pharmacokinetics of ALA induced protoporphyrin IX (PpIX) in lesions of urethral condylomata acuminata. Methods: Sixty patients (20 - 60 years old, 48 male and 12 female) with urethral condylomata acuminata were divided randomly into 5 groups to receive different concentrations of ALA solution (0.5, 1, 3, 5 or 10%). The ALA solution was applied topically to the lesion for a different length of time (1, 3, 5 or 7 h). Biopsy was performed at the end of incubation and specimens were subjected to histological and PpIX fluorescence analyses. Results: ALA-induced PpIX fluorescence was dominantly distributed in the epidermis. The maximal fluorescence intensity was detected at the 5 h of incubation. Higher ALA concentration (e.g. 5 and 10%) produced stronger intensity. In contrast, only the minimal amount of PpIX fluorescence was detected in the dermis. Conclusions: The results suggest that the topical application of 5 - 10% ALA solution for 3-5 h are the optimal conditions for ALA/PpIX-mediated photodynamic therapy for the treatment of urethral condylomata acuminata.

Paper Details

Date Published: 13 February 2007
PDF: 9 pages
Proc. SPIE 6438, Biophotonics and Immune Responses II, 64380A (13 February 2007); doi: 10.1117/12.705732
Show Author Affiliations
Xiu-Li Wang, Shanghai Skin Diseases and STD Hospital (China)
Hong-Wei Wang, Shanghai Skin Diseases and STD Hospital (China)
Zheng Huang, Univ. of Colorado at Denver and Health Sciences Ctr. (United States)
Herbert Stepp, Munich Univ. (Germany)
Reinhold Baumgartner, Munich Univ. (Germany)
Christian Dannecker, Munich Univ. (Germany)
Peter Hillemanns, Medical School of Hannover (Germany)

Published in SPIE Proceedings Vol. 6438:
Biophotonics and Immune Responses II
Wei R. Chen, Editor(s)

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