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Proceedings Paper

BioMEMS for the determination of rheological properties of biological fluids
Author(s): Andrei Marius Avram; Marioara Avram; Ciprian Iliescu; Marius Volmer
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Paper Abstract

The purpose of this research was to model, design and fabricate a biodynamic analysis microsystem required for the determination of various molecular transport properties of the non-Newtonian biological fluids. In order to achieve this, a lab-on-a-chip device is studied. The microsystem consists of a microchannels system and gear wheels for the rotator pump and for the detection system. The microchannel system developed satisfies the objectives for the study of microcirculation and characterization of cell rheological properties, functions and behavior. The microchannel types are: straight, bifurcated, stenosed and endothelial profiled. Some simulations were made in order to provide an idea about blood flow through blood vessels and microchannels. The gear wheel was fabricated using the silicon surface micromachining technology, combining the undercut and refill technique with pin-joint bearing permitting the fabrication of bushings. A giant magnetoresistive sensor with a non-contacting transduction mechanism, in full Wheatstone bridge configurations with four active resistors in the middle of the sensitive structure and four shielded reference resistors, very attractive for detection of low magnetic fields in lab-on-a-chip applications, is used to transform the rotor rotation rate into an electrical signal.

Paper Details

Date Published: 20 December 2006
PDF: 11 pages
Proc. SPIE 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III, 64150V (20 December 2006); doi: 10.1117/12.705353
Show Author Affiliations
Andrei Marius Avram, National Institute for Research and Development in Microtechnologies (Romania)
Marioara Avram, National Institute for Research and Development in Microtechnologies (Romania)
Ciprian Iliescu, Institute of Bioengineering and Nanotechnologies (Singapore)
Marius Volmer, Transilvania Univ. of Brasov (Romania)


Published in SPIE Proceedings Vol. 6415:
Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III
Jung-Chih Chiao; Andrew S. Dzurak; Chennupati Jagadish; David Victor Thiel, Editor(s)

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