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Proceedings Paper

Luminescent lanthanide-ion doped nanoparticles as single-biomolecule labels and oxidant sensors
Author(s): D. Casanova; D. Giaume; M. Moreau; T. Gacoin; J. P. Boilot; A. Alexandrou
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Paper Abstract

We report on the single-particle properties of lanthanide-ion doped oxide nanoparticles. We have demonstrated that their size can be accurately determined from their luminosity. The optically determined size distribution is in very good agreement with the distribution obtained from transmission electron microscopy (TEM). We also showed that the photobleaching of these nanoparticles is related to a reduction process and that we can use it to sense in a concentration-dependent manner the presence of an oxidant like H2O2. Finally, we propose a way to perform nanoparticle-protein coupling and to determine the protein-nanoparticle ratio at the single-particle level.

Paper Details

Date Published: 27 February 2007
PDF: 9 pages
Proc. SPIE 6448, Colloidal Quantum Dots for Biomedical Applications II, 64480F (27 February 2007); doi: 10.1117/12.705067
Show Author Affiliations
D. Casanova, Lab. for Optics and Biosciences, Ecole Polytechnique, CNRS (France)
D. Giaume, Lab. of Condensed Matter Physics, Ecole Polytechnique, CNRS (France)
M. Moreau, Lab. of Condensed Matter Physics, Ecole Polytechnique, CNRS (France)
T. Gacoin, Lab. of Condensed Matter Physics, Ecole Polytechnique, CNRS (France)
J. P. Boilot, Lab. of Condensed Matter Physics, Ecole Polytechnique, CNRS (France)
A. Alexandrou, Lab. for Optics and Biosciences, Ecole Polytechnique, CNRS (France)


Published in SPIE Proceedings Vol. 6448:
Colloidal Quantum Dots for Biomedical Applications II
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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