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Proceedings Paper

Ultrahigh-resolution adaptive optics - optical coherence tomography: toward isotropic 3-um resolution for in vivo retinal imaging
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Paper Abstract

Ultrahigh axial resolution in adaptive optics - optical coherence tomography (AO-OCT) is fundamentally limited by the intrinsic chromatic aberrations of the human eye. Variation in refractive index of the ocular media with wavelength causes the spectral content of broadband light sources to focus at different depths in the retina for light entering the eye and at the imaging detector for light exiting. This effect has not been previously reported for ultrahigh-resolution OCT (without AO) likely because the effect is masked by the relatively long depth of focus dictated by the small pupils used in these systems. With AO, the pupil size is much larger and depth of focus substantially narrower. As such the chromatic aberrations of the eye can counteract the lateral resolution benefit of AO when used with broadband light sources. To more fully tap the potential of AO-OCT, compensation of the eye's chromatic and monochromatic aberrations must occur concurrently. One solution is to insert an achromatizing lens in front of the eye whose chromatic aberrations are equal but opposite in sign to that of the eye. In this paper we evaluate the efficacy of a novel design that uses a custom achromatizing lens placed near the fiber collimating optic. AO-OCT images are acquired on several subjects with and without the achromatizing lens and in combination with two light sources of different spectral width. The combination of the achromatizing lens and broadband light source yielded the sharpest images of the retina and the smallest speckle.

Paper Details

Date Published: 9 February 2007
PDF: 9 pages
Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 642909 (9 February 2007); doi: 10.1117/12.704639
Show Author Affiliations
Robert J. Zawadzki, Univ. of California, Davis (United States)
Yan Zhang, Indiana Univ. (United States)
Steven M. Jones, Lawrence Livermore National Lab. (United States)
R. Daniel Ferguson, Physical Sciences Inc. (United States)
Stacey S. Choi, Univ. of California, Davis (United States)
Barry Cense, Indiana Univ. (United States)
Julia W Evans, Lawrence Livermore National Lab. (United States)
Diana Chen, Lawrence Livermore National Lab. (United States)
Donald T. Miller, Indiana Univ. (United States)
Scot S. Olivier, Lawrence Livermore National Lab. (United States)
John S. Werner, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 6429:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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