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Proceedings Paper

SDOCT Doppler velocimetry for investigating the morphological influences on blood flow in the developing chick embryo heart
Author(s): Anjul M. Davis; Florence G. Rothenberg; Tzuo H. Law; Larry A. Taber; Joseph A. Izatt
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Paper Abstract

The onset of congenital heart disease (CHD) is believed to occur at very early stages of development. Investigations in the initiation and development of CHD has been hampered by the inability to image early stage heart structure and function, in vivo. Imaging small animals using optical coherence tomography (OCT) has filled a niche between the limited penetration depth of confocal microscopy and insufficient resolution from ultrasound. Previous demonstrations of chick heart imaging using OCT have entailed excision of, or arresting the heart to prevent motion artifacts. In this summary, we introduce SDOCT Doppler velocimetry as an enhancement of Doppler OCT for in vivo measurement of localized temporal blood flow dynamics. With this technique, dynamic velocity waveforms were measured in the outflow tract of the heart tube. These flow dynamics correlate to a finite element model of pulsatile flow and may lead to a further understanding of morphological influences on early heart development.

Paper Details

Date Published: 7 February 2007
PDF: 4 pages
Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 64290R (7 February 2007); doi: 10.1117/12.703382
Show Author Affiliations
Anjul M. Davis, Duke Univ. (United States)
Florence G. Rothenberg, Duke Univ. Medical Ctr. (United States)
Tzuo H. Law, Duke Univ. (United States)
Larry A. Taber, Washington Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 6429:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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