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Proceedings Paper

Ultrasound interstitial thermal therapy (USITT) for the treatment of uterine myomas
Author(s): William H. Nau; Chris J. Diederich; Jeff Simko M.D.; Titania Juang; Alison Jacoby M.D.; E. Clif Burdette
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Paper Abstract

Uterine myomas (fibroids) are the most common pelvic tumors occurring in women, and are the leading cause of hysterectomy. Symptoms can be severe, and traditional treatments involve either surgical removal of the uterus (hysterectomy), or the fibroids (myomectomy). Interstitial ultrasound technologies have demonstrated potential for hyperthermia and high temperature thermal therapy in the treatment of benign and malignant tumors. These ultrasound devices offer favorable energy penetration allowing large volumes of tissue to be treated in short periods of time, as well as axial and angular control of heating to conform thermal treatment to a targeted tissue, while protecting surrounding tissues from thermal damage. The goal of this project is to evaluate interstitial ultrasound for controlled thermal coagulation of fibroids. Multi-element applicators were fabricated using tubular transducers, some of which were sectored to produce 180° directional heating patterns, and integrated with water cooling. Human uterine fibroids were obtained after routine myomectomies, and instrumented with thermocouples spaced at 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 cm from the applicator. Power levels ranging from 8-15 W per element were applied for up to 15 minute heating periods. Results demonstrated that therapeutic temperatures >50° C and cytotoxic thermal doses (t43) extended beyond 2 cm radially from the applicator (>4 cm diameter). It is anticipated that this system will make a significant contribution toward the treatment of uterine fibroids.

Paper Details

Date Published: 10 March 2007
PDF: 8 pages
Proc. SPIE 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV, 64400F (10 March 2007); doi: 10.1117/12.703220
Show Author Affiliations
William H. Nau, Univ. of California, San Francisco (United States)
Chris J. Diederich, Univ. of California, San Francisco (United States)
Jeff Simko M.D., Univ. of California, San Francisco (United States)
Titania Juang, Univ. of California, San Francisco (United States)
Alison Jacoby M.D., Univ. of California, San Francisco (United States)
E. Clif Burdette, Acoustic MedSystems, Inc. (United States)


Published in SPIE Proceedings Vol. 6440:
Thermal Treatment of Tissue: Energy Delivery and Assessment IV
Thomas P. Ryan, Editor(s)

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