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Proceedings Paper

Prostate thermal therapy with catheter-based ultrasound devices and MR thermal monitoring
Author(s): Will H. Nau; Chris J. Diederich; Adam Kinsey; Tony Ross; Jeff Wootton; Titania Juang; Kim Butts-Pauly; Viola Ricke; Erin H. Liu; Jing Chen; Donna M. Bouley; Maurice Van den Bosch; Graham Sommer M.D.
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Paper Abstract

Four types of transurethral applicators were devised for thermal ablation of prostate combined with MR thermal monitoring: sectored tubular transducer devices with directional heating patterns; planar and curvilinear devices with narrow heating patterns; and multi-sectored tubular devices capable of dynamic angular control without applicator movement. These devices are integrated with a 4 mm delivery catheter, incorporate an inflatable cooling balloon (10 mm OD) for positioning within the prostate and capable of rotation via an MR-compatible motor. Interstitial devices (2.4 mm OD) have been developed for percutaneous implantation with directional or dynamic angular control. In vivo experiments in canine prostate under MR temperature imaging were used to evaluate the heating technology and develop treatment control strategies. MR thermal imaging in a 0.5 T interventional MRI was used to monitor temperature and thermal dose in multiple slices through the target volume. Sectored tubular, planar, and curvilinear transurethral devices produce directional coagulation zones, extending 15-20 mm radial distance to the outer prostate capsule. Sequential rotation and modulated dwell time can conform thermal ablation to selected regions. Multi-sectored transurethral applicators can dynamically control the angular heating profile and target large regions of the gland in short treatment times without applicator manipulation. Interstitial implants with directional devices can be used to effectively ablate the posterior peripheral zone of the gland while protecting the rectum. The MR derived 52 °C and lethal thermal dose contours (t43=240 min) allowed for real-time control of the applicators and effectively defined the extent of thermal damage. Catheter-based ultrasound devices, combined with MR thermal monitoring, can produce relatively fast and precise thermal ablation of prostate, with potential for treatment of cancer or BPH.

Paper Details

Date Published: 9 February 2007
PDF: 10 pages
Proc. SPIE 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV, 64400D (9 February 2007); doi: 10.1117/12.703184
Show Author Affiliations
Will H. Nau, Univ. of California, San Francisco (United States)
Chris J. Diederich, Univ. of California, San Francisco (United States)
Adam Kinsey, Univ. of California, San Francisco (United States)
Tony Ross, Univ. of California, San Francisco (United States)
Jeff Wootton, Univ. of California, San Francisco (United States)
Titania Juang, Univ. of California, San Francisco (United States)
Kim Butts-Pauly, Stanford Univ. (United States)
Viola Ricke, Stanford Univ. (United States)
Erin H. Liu, Stanford Univ. (United States)
Jing Chen, Stanford Univ. (United States)
Donna M. Bouley, Stanford Univ. (United States)
Maurice Van den Bosch, Stanford Univ. (United States)
Graham Sommer M.D., Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 6440:
Thermal Treatment of Tissue: Energy Delivery and Assessment IV
Thomas P. Ryan, Editor(s)

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