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Proceedings Paper

Enhanced gold nanoshell scattering contrast in cervical tissue using angled fiber probes
Author(s): Vengadesan Nammalvar; Adrien Wang; Rebekah Drezek
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Paper Abstract

Diffuse reflectance of cervical tissue treated with gold nanoshells is collected at 0 and 40 degrees, measured from the perpendicular to tissue surface. Between the two collection angles, the infused nanoshells exhibit much stronger scattering signals in contrast to the ordinary reflectance attributed to the naked tissue when the collection angle of the fiber probe is obliquely oriented at 40 degrees. At 0 deg. fiber angle, no significant differentiation is observed between naked and nanoshell-treated tissue samples. This result indicates a strong potential of combining angularly-variable reflectance spectroscopy and gold nanoshells in order to achieve synergistically enhanced scattering contrast in tissue.

Paper Details

Date Published: 10 February 2007
PDF: 10 pages
Proc. SPIE 6447, Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV, 64470H (10 February 2007); doi: 10.1117/12.702910
Show Author Affiliations
Vengadesan Nammalvar, Rice Univ. (United States)
Adrien Wang, Rice Univ. (United States)
Rebekah Drezek, Rice Univ. (United States)

Published in SPIE Proceedings Vol. 6447:
Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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