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Proceedings Paper

Acoustic fingerprints of photoacoustic contrast agents for molecular imaging
Author(s): Michael A. McDonald; Ladislav Jankovic; Khalid Shahzad; Michael Burcher; King C.P. Li
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Paper Abstract

Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.

Paper Details

Date Published: 13 February 2007
PDF: 9 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370L (13 February 2007); doi: 10.1117/12.702355
Show Author Affiliations
Michael A. McDonald, Stanford Univ. (United States)
Ladislav Jankovic, Philips Research (United States)
Khalid Shahzad, Philips Research (United States)
Michael Burcher, Philips Research (United States)
King C.P. Li, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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