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Proceedings Paper

Two-dimensional/three-dimensional hybrid interstitial diffuse optical tomography of human prostate during photodynamic therapy: phantom and clinical results
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Paper Abstract

We have developed an efficient Levenberg-Marquardt iterative algorithm utilizing a three-dimensional field measurements coupled to a two-dimensional optical property reconstruction scheme. This technique takes advantage of accurate estimation of light distribution in 3D forward calculation and reduced problem size and less computation time in 2D inversion. Important advances in terms of improving algorithm efficiency and accuracy include use of an iterative general minimum residual method (GMRES) for computing the field solutions, application of the dual mesh scheme and adjoint method for Jacobian construction, and implementation of normalization scheme to reduce the absorption-scattering cross talk. The synthetic measurement data were calculated for a cubic phantom containing a single absorption anomaly and a single scattering anomaly. The model had a background of &mgr;a=0.03mm-1 and &mgr;s=1.4mm-1. The absorption and scattering anomalies have the &mgr;a = 0.06 mm-1 and &mgr;s' = 2.0 mm-1. Five sources and 72 detectors are used per slice. A typical human prostate is composed of 6 slices. The reconstruction images successfully recover the both anomalies with good localization. Experiment data from tissue simulated phantom are also presented. The clinical DOT imaging was performed before photodynamic therapy based on the protocol. The preliminary results showed the reconstructed prostate &mgr;a varied between 0.025 and 0.07 mm-1 and &mgr;s' ranged from 1.1 to 2 mm-1. These results show that this new 2D-3D hybrid algorithm consistently outperform the 2D-2D or 3D-3D counterparts.

Paper Details

Date Published: 14 February 2007
PDF: 11 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64341Y (14 February 2007); doi: 10.1117/12.701717
Show Author Affiliations
Xiaodong Zhou, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Jun Li, Univ. of Pennsylvania (United States)
Andreea Dimofte, Univ. of Pennsylvania (United States)
Stephen M. Hahn, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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