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Proceedings Paper

Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect
Author(s): Zhongzhen Mao; Ying Zheng; Yating Hu; Wei Lu; Qingming Luo; Dan Zhu
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Paper Abstract

In order to discuss the relative factors affecting the optical clearing effect of agents on skin tissues, six hydroxy-terminated and saturated alcohols with different refractive index and molecular weight were chosen as the optical clearing agents (OCAs). After being treated by different OCAs, the change of transmitted intensity of porcine skins in vitro was measured by single integrating sphere system. The results showed the optical clearing effects of six OCAs, i.e., glycerol, PEG400, PEG200, 1,3-propylene glycol, 1,4-butanediol and 1-butanol, arranged in the descending order. Based on the above results, the refractive index and molecular weight was further discussed. The optical clearing effect of alcohols has been deduced to have negative correlation with refractive index (r=-0.608), but no correlation with molecular weight (r= 0.008).

Paper Details

Date Published: 7 February 2007
PDF: 7 pages
Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 64360O (7 February 2007); doi: 10.1117/12.701701
Show Author Affiliations
Zhongzhen Mao, Wuhan Institute of Physical Education (China)
Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Ying Zheng, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Yating Hu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Wei Lu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Dan Zhu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6436:
Complex Dynamics and Fluctuations in Biomedical Photonics IV
Valery V. Tuchin, Editor(s)

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