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Proceedings Paper

Tissue bound water studies on breast tumors using diffuse optical spectroscopy
Author(s): So Hyun Chung; Albert Cerussi; Sean Merritt; David Hsiang; Rita Mehta; Bruce J. Tromberg
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Paper Abstract

Differences in tissue water state have been measured in normal and malignant breast tissues. Broadband Diffuse Optical Spectroscopy (DOS) has been used to acquire 650-1000 nm absorption spectra of normal and tumor breast tissues from 7 patients in vivo. The absolute values of spectral differences between normalized tissue water spectra and pure water spectra were combined and divided by the number of points in the sum to form the bound water index (BWI). In all subjects, the average BWIs of line scan points were significantly lower in tumor tissues (1.62 ± 0.27 x10-3) than normal tissues (3.06 ±0.51 x10-3, Wilcoxon Ranked Sum Test z= 0.003 and power=0.98). These results imply that the water in tumors behaves more like free water than the water in normal tissue.

Paper Details

Date Published: 27 March 2007
PDF: 5 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64341F (27 March 2007); doi: 10.1117/12.701692
Show Author Affiliations
So Hyun Chung, Beckman Laser Institute, Univ. of California, Irvine (United States)
Albert Cerussi, Beckman Laser Institute, Univ. of California, Irvine (United States)
Sean Merritt, Masimo Corp. (United States)
David Hsiang, Univ. of California Irvine Medical Ctr. (United States)
Rita Mehta, Univ. of California Irvine Medical Ctr. (United States)
Bruce J. Tromberg, Beckman Laser Institute, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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