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Proceedings Paper

Multifunctional nanoparticles for drug/gene delivery in nanomedicine
Author(s): Mary-Margaret Seale; Dimitry Zemlyanov; Christy L. Cooper; Emily Haglund; Tarl W. Prow; Lisa M. Reece; James F. Leary
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Paper Abstract

Multifunctional nanoparticles hold great promise for drug/gene delivery. Multilayered nanoparticles can act as nanomedical systems with on-board "molecular programming" to accomplish complex multi-step tasks. For example, the targeting process has only begun when the nanosystem has found the correct diseased cell of interest. Then it must pass the cell membrane and avoid enzymatic destruction within the endosomes of the cell. Since the nanosystem is only about one millionth the volume of a human cell, for it to have therapeutic efficacy with its contained package, it must deliver that drug or gene to the appropriate site within the living cell. The successive de-layering of these nanosystems in a controlled fashion allows the system to accomplish operations that would be difficult or impossible to do with even complex single molecules. In addition, portions of the nanosystem may be protected from premature degradation or mistargeting to non-diseased cells. All of these problems remain major obstacles to successful drug delivery with a minimum of deleterious side effects to the patient. This paper describes some of the many components involved in the design of a general platform technology for nanomedical systems. The feasibility of most of these components has been demonstrated by our group and others. But the integration of these interacting sub-components remains a challenge. We highlight four components of this process as examples. Each subcomponent has its own sublevels of complexity. But good nanomedical systems have to be designed/engineered as a full nanomedical system, recognizing the need for the other components.

Paper Details

Date Published: 10 February 2007
PDF: 9 pages
Proc. SPIE 6447, Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV, 64470E (10 February 2007); doi: 10.1117/12.701645
Show Author Affiliations
Mary-Margaret Seale, Purdue Univ. (United States)
Dimitry Zemlyanov, Purdue Univ. (United States)
Christy L. Cooper, Purdue Univ. (United States)
Emily Haglund, Purdue Univ. (United States)
Tarl W. Prow, Johns Hopkins Univ. (United States)
Lisa M. Reece, Purdue Univ. (United States)
James F. Leary, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 6447:
Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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