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Proceedings Paper

Short and ultrashort laser pulse induced bubbles on transparent and scattering tissue models
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Paper Abstract

Bubble formation is a well identified phenomenon within short (ns) and ultrashort (fs) laser pulses-aqueous media interactions. Bubble formation might be produced by three different mechanisms: (1) optical breakdown, (2) rarefraction wave and (3) overheating of the material. Experiments where transparent and scattering tissue models that mimic biological tissue were irradiated with a Q-switched, 532 nm, 5 nanosecond, Nd:YAG and Ti:sapphire femtosecond laser systems. The type of bubble (transient or permanent) and initial bubble diameter were characterized as a function of time as well as the number of pulses and repetition rate at which they were delivered. Threshold fluence for bubble formation in scattering tissue model was also studied. Two types of bubbles were identified depending on the number of pulses and the repetition rate at which they were delivered: transient (type 1) and permanent (type 2) bubbles. There is an insignificant difference in the fluence required to form a bubble in transparent tissue models regardless of the depth at which the beam was focused; in contrast, for scattering tissue models, the fluence required to form a bubble in deep positions is significantly higher than that of more superficial beam focus positions.

Paper Details

Date Published: 21 February 2007
PDF: 8 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350V (21 February 2007); doi: 10.1117/12.701566
Show Author Affiliations
Francisco Pérez-Gutierrez, Univ. of California, Riverside (United States)
Rodger Evans, Ctr. de Investigación Científica y de Educación Superior de Ensenada (Mexico)
Santiago Camacho-Lopez, Ctr. de Investigación Científica y de Educación Superior de Ensenada (Mexico)
Guillermo Aguilar, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)

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