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Proceedings Paper

Comparison of three thermotherapy modalities for the ablation of mamma carcinoma in situ using thermal imaging and mapping
Author(s): John H. G. M. Klaessens; Rudolf Verdaasdonk; Stijn van Esser; Andriy Shmatukha; Tjeerd de Boorder; Richard van Hillegersberg
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Paper Abstract

A larger percentage of small tumors in the breast are being detected due to effective screening programs and improved radiological diagnostic methods. For treatment, less invasive methods are preferred which are still radical but also provide a better aesthetic result. Recently, several ablation techniques have become available to locally ablate tumors in situ. In this study, the effectiveness of three ablation techniques was compared by imaging the thermal distribution and temperature mapping in vitro. The first system (KLS Martin, Trumpf, Germany) uses Nd:YAG laser light delivered through a single diffusing fiber tip which is positioned direct into the tissue or in a water-cooled needle. The second system (Olympus-Celon, Germany) uses bipolar Radio Frequency currents between electrodes in a water-cooled needle. The RF system has a temperature feedback based on tissue impedance to prevent tissue charring. The third system is a focused ultrasound system developed in the Hospital. For all three the techniques, the dynamics of temperature gradients around the probe or focus point are visualized using color Schlieren techniques in a transparent tissue model and recorded using thermocouples. The effective lesion size and tissue temperatures were determined in in vitro bovine mamma tissue. All systems were capable to heat tissue volumes up to 3 cm in diameter. The lesion growth dependent on the power input, temperature gradient around the initial power source and treatment time. Although the three systems are capable to ablate small mamma carcinoma in situ, they differ in precision, MR compatibility, invasiveness, practical use and treatment time. The real clinical effectiveness has to be proven in large patient studies with long term follow up.

Paper Details

Date Published: 9 February 2007
PDF: 12 pages
Proc. SPIE 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV, 64400A (9 February 2007); doi: 10.1117/12.701368
Show Author Affiliations
John H. G. M. Klaessens, Univ. Medical Ctr. Utrecht (Netherlands)
Rudolf Verdaasdonk, Univ. Medical Ctr. Utrecht (Netherlands)
Stijn van Esser, Univ. Medical Ctr. Utrecht (Netherlands)
Andriy Shmatukha, Univ. Medical Ctr. Utrecht (Netherlands)
Tjeerd de Boorder, Univ. Medical Ctr. Utrecht (Netherlands)
Richard van Hillegersberg, Univ. Medical Ctr. Utrecht (Netherlands)


Published in SPIE Proceedings Vol. 6440:
Thermal Treatment of Tissue: Energy Delivery and Assessment IV
Thomas P. Ryan, Editor(s)

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