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Proceedings Paper

A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment
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Paper Abstract

Multi-sensory fiber-optic probes using nanocrystals as the sensing materials are shown to overcome most limitations imposed by those using organic dyes as the fluence-rate sensing materials. These nanocrystals are shown to be excitable by a wide range of wavelengths covering the entire tissue transparent window utilized by various light-enabled treatment modalities. The optical response of the sensors made from the nanocrystals is shown to be linear without any sign of photobleaching and sensor crosstalk over a wide range of irradiance and fluence. Fiber probes using the nanocrystals are promising in offering high spatial resolution in fluence-rate dosimetry for photodynamic therapy and photothermal treatment.

Paper Details

Date Published: 28 February 2007
PDF: 9 pages
Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64271B (28 February 2007); doi: 10.1117/12.701274
Show Author Affiliations
Tung-Wah Frederick Chang, Princess Margaret Hospital (Canada)
Mari Boesen, Princess Margaret Hospital (Canada)
Robert Weersink, Princess Margaret Hospital (Canada)
Luc Charron, Princess Margaret Hospital (Canada)
Edward H. Sargent, Univ. of Toronto (Canada)
Lothar Lilge, Princess Margaret Hospital (Canada)


Published in SPIE Proceedings Vol. 6427:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
David Kessel, Editor(s)

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