Share Email Print
cover

Proceedings Paper

Using fluorescence molecular tomography for multimodality fusion imaging
Author(s): Sunder Balasubramanian; Brian Carmignani; Naresh Kujala; Domingo Pacheco; Lixin Ma; Charles Smith; Timothy Hoffman; Wynn Volkert; Ping Yu
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Multimodality molecular imaging that combines anatomical and functional information has shown promise in development of tumor-targeted pharmaceuticals for cancer detection or therapy. Most multimodality imaging techniques are based on nuclear imaging modalities and MRI or CT. Fluorescence molecular tomography (FMT) is an emerging optical modality for non-invasive functional imaging and early diagnosis of carcinoma. Three-dimensional FMT can differentiate tissue physiological changes in vivo to provide functional information when used in conjunction with cancer cell selectively targeted probes. In this study, we present the design of such a system for multimodality molecular imaging. A frequency domain radio frequency technique based on commercial amateur radio equipment has been developed. A heterodyne method is used to transfer a low frequency oscillation into a single-side-band at radio frequency. The difference in phase, caused by fluorescence photon density wave, is detected between a transmitting fiber and a receiving fiber bundle, and then measured at lower frequency after demodulation. To achieve multimodality molecular imaging, a new fluorescent labeled tumor-targeting probe, fluorescent bombesin conjugates, has been developed with high affinity and specificity for targeting breast cancer cells. The developed multimodality fusion strategy will provide increased sensitivity/specificity for cancer cells, with respect to any single imaging modality.

Paper Details

Date Published: 8 February 2007
PDF: 9 pages
Proc. SPIE 6431, Multimodal Biomedical Imaging II, 643110 (8 February 2007); doi: 10.1117/12.701263
Show Author Affiliations
Sunder Balasubramanian, Univ. of Missouri, Columbia (United States)
Brian Carmignani, Univ. of Missouri, Columbia (United States)
Naresh Kujala, Univ. of Missouri, Columbia (United States)
Domingo Pacheco, Univ. of Missouri, Columbia (United States)
Lixin Ma, Univ. of Missouri, Columbia (United States)
International Institute of Nano and Molecular Medicine, Univ. of Missouri, Columbia (United States)
Radiopharmaceutical Science Institute, Univ. of Missouri, Columbia (United States)
Charles Smith, Univ. of Missouri, Columbia (United States)
Radiopharmaceutical Science Institute, Univ. of Missouri, Columbia (United States)
Harry S. Truman Memorial Veterans' Hospital (United States)
Timothy Hoffman, Radiopharmaceutical Science Institute, Univ. of Missouri, Columbia (United States)
Univ. of Missouri, Columbia (United States)
Harry S. Truman Memorial Veterans' Hospital (United States)
Wynn Volkert, Univ. of Missouri, Columbia (United States)
Radiopharmaceutical Science Institute, Univ. of Missouri, Columbia (United States)
Harry S. Truman Memorial Veterans' Hospital (United States)
Ping Yu, Univ. of Missouri, Columbia (United States)


Published in SPIE Proceedings Vol. 6431:
Multimodal Biomedical Imaging II
Fred S. Azar, Editor(s)

© SPIE. Terms of Use
Back to Top