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Proceedings Paper

NAOMI: nanoparticle-assisted optical molecular imaging
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Paper Abstract

We present our first steps towards nanoparticle assisted, optical molecular imaging (NAOMI) using biodegradable nanoparticles. Our focus is on using optical coherence tomography(OCT) as the imaging modality. We propose to use nanoparticles based on biodegradable polymers, loaded with carefully selected dyes as contrast agent, and outline a method for establishing their desired optical properties prior to synthesis. Moreover, we perform a qualitative pilot study using these biodegradable nanoparticles, measuring their optical properties which are found to be in line with theoretical predictions.

Paper Details

Date Published: 12 February 2007
PDF: 9 pages
Proc. SPIE 6447, Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV, 64470I (12 February 2007); doi: 10.1117/12.701262
Show Author Affiliations
Dirk J. Faber, Academic Medical Ctr. (Netherlands)
Martijn de Bruin, Academic Medical Ctr. (Netherlands)
Maurice C. G. Aalders, Academic Medical Ctr. (Netherlands)
Frank D. Verbraak, Academic Medical Ctr. (Netherlands)
Ton G. van Leeuwen, Academic Medical Ctr. (Netherlands)
Univ. of Twente (Netherlands)


Published in SPIE Proceedings Vol. 6447:
Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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